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Traditional concerns about anti-obesity therapies inadvertently exacerbating bone loss have thus been partially allayed by this work, though the authors emphasize the necessity of prospective, longitudinal studies to robustly validate these retrospective observations and unravel the underlying biological pathways

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to reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established cardiovascular disease and either obesity or overweight