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NNMT sits at high levels in fat tissue, in many cancer cells and in tissue under metabolic stress, where it acts as a metabolic sink: it consumes NAD+, the coenzyme that powers energy production and cell repair, and S-adenosylmethionine (SAM), the cells main methyl-group donor
Laboratory protocols explore how senescent T cells, B cells, and other immune cells contribute to age-related immune dysfunction, while FOXO4-DRI administration provides researchers with methods for testing immune system restoration following senescent cell elimination
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