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Regarding other flavonoid compounds, licorice-glabiridin (91), the main component found in the hydrophobic fraction of licorice extracts (92), has previously been demonstrated to exhibit inhibitory activity against TYR in B16 murine melanoma cells (93,94)

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Tyrosinase enzyme upregulation the mechanism that converts tyrosine into melanin takes 4872 hours to reach peak activity after MT2 binds melanocortin receptors

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