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Notably, in contrast to 23 (HA08), a structurally very similar epimer (HA09) which differs only with regard to one stereogenic center and exhibiting a 100-fold lower affinity to IRAP did not affect spine morphology, indicating a correlation between the capacity to inhibit IRAP and a positive impact on DSD and spine morphology

Dihexas positioning is specifically through the HGF/c-Met receptor system with downstream PI3K/AKT signaling and dendritic spinogenesis as the major in vitro readout

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