25 Another systemic benefit of GLP-1RA is its improvement of lipid metabolism
Muscle and Fat (Insulin Sensitivity): GLP-1 RAs enhance glucose uptake in muscle and adipose tissue via the PI3K/Akt pathway, improving overall insulin sensitivity (Zheng et al., 2024)
Always talk with your healthcare practitioner before beginning any new supplement, especially if youre already taking medications.
Others may develop worsening gastrointestinal symptoms, including severe bloating, constipation, or nausea
Shilpa Paradkar Singh, MD | Last reviewed June 2026 Access to the latest FDA-approved medications tailored to your biology
Comparative Effectiveness of Once-Weekly Glucagon-Like Peptide-1 Receptor Agonists With Regard to 6-Month Glycaemic Control and Weight Outcomes in Patients With Type 2 Diabetes