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Data Availability Statement The data that support the findings of this study are available on request from the corresponding author.

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With aging, cumulative alterations occur across all layers of this multilayered structure, resulting in impaired barrier integrity, diminished regenerative capacity, and increased susceptibility to environmental insults [33]

This is distinct from stimulants or acetylcholinesterase inhibitors, which modulate neurotransmitter availability rather than synaptic architecture