Currently, this is only a theory
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Theranostics 7 (13), 32933305
Suppression of food and water intake by GLP-1 mainly involves interactions with various hypothalamic nuclei, particularly the arcuate and paraventricular nucleus, as well as some hindbrain structures such as the parabrachial nucleus [31]
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"With GLP-1 medications reducing appetite significantly, we're not just aiming for a calorie deficit anymore