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The addition of oxygen during HMP is aimed at reducing ischaemiareperfusion injury, but has shown mixed results in kidney transplantation, often depending on the duration of perfusion, although some studies found that the addition of oxygen improved outcomes in higher-risk donors
In addition, the activity and expression of SLC7A11 is strictly regulated by multiple mechanisms, such as transcription factor 4 (ATF4), nuclear factor erythroid 2related factor 2 (NRF2), ubiquitin BRCA1 (Breast cancer gene 1)-associated protein-1 (BAP1), the SWI/SNF complex, and rapamycin complex 1 (mTORC1) (51), through which the expression of SLC7A11 can be upregulated to enhance the antioxidant defense of cells and inhibit the occurrence of ferroptosis ( Figure 1B )
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