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Pro-inflammatory mediators are then produced due to intracellular signaling events, which can harm the tissue and worsen the inflammatory response

doi: 10.3390/ph18121822

Research in prairie voles demonstrated that peripheral administration of Melanotan II facilitated partner preference formationa laboratory measure of social bondingand these effects were blocked by oxytocin receptor antagonists, confirming oxytocin system dependence

Cultures were subsequently cooled in an ice water bath for 15 min and centrifuged (4.000 g , 15 min, 4 C)

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