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Exogenous AAS inhibit endogenous testosterone production, and discontinuation of their use is often associated with a prolonged decrease in testosterone secretion (Kanayama et al., 2015
Also, individuals with COMT defects can be at higher risk for accumulating too much peroxynitrites which builds up in their bodies, causing stiffness and muscle pain or brain fog and cardiovascular problems
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But for most researchers, following strict storage protocols and adhering to shelf-life guidelines is the more practical approach
