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It activates one of the body's master regulators of metabolism, an enzyme called AMP kinase, triggering some of the same benefits that fasting and exercise provide to our cells

The subsequent development of tirzepatide, a dual GIP and GLP-1 receptor agonist, demonstrated that targeting multiple gut hormone pathways could yield superior efficacy [9, 11]

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This is largely attributed to the GIP component's role in adipose tissue health and the secondary effects of reduced caloric intake