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In addition, symptom relief following abstinence helps define CHS, according to the Rome IV criteria (Table 1)

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Age, sex, nutritional status, adiposity, dietary preferences, habits such as smoking, use of concurrent medications, physiologic states such as pregnancy, pathologic states such as liver disease, and others can affect one or more of the 3 processes listed above, thereby influencing the half-life of psychotropic and other drugs

A diverse gut microbiome produces more varied short-chain fatty acids and supports more robust GLP-1 signaling than a microbiome dominated by just a few bacterial species

The Ex(9-39) treatment, compared with saline, itself significantly elevated blood glucose levels (Fig

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