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IHC staining was performed as previously described [30]

Animals were exposed to standard chow or an HFD during metabolic assessment (as indicated)

The dual-agonist format uses the same cagrilintide + semaglutide pairing that delivered a 14.2% mean body-weight reduction at 68 weeks in Novo Nordisk's April 2024 Phase 3 type 2 diabetes readout, versus 10.2% for semaglutide alone [3]

If your high B12 is from supplements or injections, stopping or reducing the dose will allow levels to return to normal over weeks to months