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The Phase 2 trial showed 24.2% weight loss at 48 weeks, and Phase 3 data suggests 28.7% at 68 weeks

Tirzepatide is a groundbreaking FDA-approved injection designed for weight loss that functions by imitating two key hormones that naturally manage appetite and blood sugar: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide)

These cells release GLP-1 in response to nutrient intake, particularly carbohydrates and fats

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The following framework illustrates key distinctions that should guide provider conversations

However, its primary mechanism is AMPK activationsimilar to metforminrather than GLP-1 manipulation