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Sitohang, MD, PhD

In published preclinical work, inhibiting NNMT is associated with elevated intracellular NAD and SAM, reduced lipogenesis and smaller adipocytes in cell and diet-induced-obese rodent models, and is studied in the context of insulin sensitivity and muscle function

it supports the liver's natural ability to do its job more efficiently

Keap1-nrf2 protein-protein interaction inhibitors: design, pharmacological properties and therapeutic potential

In ALD, ethanol metabolism via hepatocyte CYP2E1 generates excess ROS and acetaldehyde, inducing endoplasmic reticulum stress and mitochondrial dysfunction [365]

Moreover, in a xenograft mammary 4T1 tumor model, it has been demonstrated that the concurrent administration of BAPN and the enzyme-responsive drug (NQO1-SN38), designed to target breast tumors with the topoisomerase I inhibitor SN38, results in a cooperative reduction in tumor growth [100]