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Not everyone who started this trial ended up enjoying taking liraglutide every day

Another important feature of the trial design is that the starting dose always remained once weekly

eLife 5 , e12225 (2016)

Jiang et al., 2006

Regular IGF-1 clears faster and requires more frequent dosing to maintain steady receptor activation, but IGF-1 LR3s extended duration simplifies protocol logistics while demanding more precise timing to avoid receptor downregulation and hypoglycemia