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358 Abnormal expression of transport proteins/receptors in the BBB, such as downregulation of LRP1 which exports A from the brain to the blood, impaired function of Pgp, and upregulation of RAGE that facilitates the entry of A from the blood into the brain, could be potential reasons for impaired A clearance and substantial accumulation in the brain

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(8) Considering the majority of these procedures are unnecessarily being performed for degenerative disc disease alone, spine surgeons should be increasingly asked why they are offering these operations to their patients A team of Japanese researchers found that patients with lumbar spinal stenosis who do not improve after nonsurgical treatments are typically treated surgically using decompressive surgery and spinal fusion surgery

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FG: Conceptualization, Funding acquisition, Supervision, Writing review & editing

Compiling data suggest now that new neurons are derived not only from stem cells, but also from a population of neuroblasts displaying a protracted maturation and ready to be engaged in adult brain circuits, under specific signals