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Likewise, C-peptide concentrations paralleled those of insulin with a significant reduction in the RETA group, which was only partially reversed to Veh concentrations after RETA-w/d (Supplementary Fig

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It has been shown that in patients with type 2 diabetes mellitus (T2DM) the response to the incretin effect is altered as a result of a severe defect in the sensitivity for GIP in the cells [4] and a reduction in food-induced GLP-1 secretion [5, 6]

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Cross-trial comparisons suggest retatrutide produces greater mean weight loss than semaglutide, though tolerability profiles are broadly similar