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Data availability Atomic coordinates and structure factors for the crystal structures of the TRF1 TRFH domain in complex with the compounds discussed herein have been deposited in the Protein Data Bank (www.wwpdb.org) and can be accessed using the PDB accession numbers provided in Supplementary Table 3

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Purity testing typically uses High Performance Liquid Chromatography to identify the peptide and assess the concentration of the target compound versus impurities

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