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566 In addition to targeting the TFs, PROTACS have also been developed against transcription co-activators with an aim to indirectly regulate TF-associated disease phenotypes

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Low potassium levels, which can lead to constipation, an irregular heartbeat, leg cramps, numbness or tingling

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Kong et al., similarly uncovered synergy between a complex I inhibitor and a mito-antioxidant in cancer cells, suggesting their ability to reduce mitochondria-derived H 2 O 2 levels as a potential mechanism of action (28)