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People also can develop a leaky blood-brain barrier or leaky respiratory tract if the glutathione system is depleted

A significant aspect of this study was the administration of a high dose (50 mg/kg) to evaluate the absorption profile effectively, overcoming the challenge posed by the endogenous production of GSH which could mask the effects of supplementation

Taniguchi A, Tsuge M, Miyahara N, Tsukahara H (2021) Reactive oxygen species and antioxidative defense in chronic obstructive pulmonary disease