Fifth, the data may not encompass all potential confounding factors that could influence the outcome of interest
What was behind that choice
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Hossain MA, Kitagaki S, Nakano D, Nishiyama A, Funamoto Y, Matsunaga T, Tsukamoto I, Yamaguchi F, Kamitori K, Dong Y, Hirata Y, Murao K, Toyoda Y, Tokuda M (2011) Rare sugar D-psicose improves insulin sensitivity and glucose tolerance in type 2 diabetes Otsuka Long-Evans Tokushima Fatty (OLETF) rats
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The dose is then increased by 0.6 mg each week until you reach the target dose of 3.0 mg daily for weight loss