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This evidence gap represents both the compounds promise and its current limitations

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In addition to GSTP1-1 inhibition, TLK199 has been shown to effectively inhibit multidrug resistance-associated protein 1 MRP1 (encoded by ABCC1 gene), which plays an essential role in multidrug resistance by its ability to effectively export an array of chemotherapeutic and other drugs out of the cell [100]

doi:10.1016/j.aller.2019.04.009