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The CIR (Cosmetic Ingredient Review) panel found it to be non-sensitizing across multiple tests and human patch tests also showed no irritation or sensitization

The cut-off, where patients with gout seem to dramatically reduce their number of flares, is when their uric acid level is taken below 6.0 mg/dL.4 With the above qualifications, attention to diet in gout patients is helpful, and especially so when first starting medication to lower the uric acid (which may, paradoxically, initially set off gout attacks)

Using medication beyond this window increases contamination risk and may reduce treatment effectiveness

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doi: 10.1021/acs.jmedchem.7b00174

Szab K, Nagy Z, Juhsz V, Zolnerciks JK, Csorba A, Tmr Z, Molnr , Pdr P, Johnson W, Bery E, Krajcsi P (2017) Species specificity profiling of rat and human organic cation/carnitine transporter Slc22a5/SLC22A5 (Octn2/OCTN2)