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Semaglutide promotes weight loss through multiple mechanisms: Appetite suppression By activating GLP-1 receptors in the brain, semaglutide reduces feelings of hunger, leading to decreased food intake

The attributes that determine how the treatment effect must be interpreted, and thus define an estimand, are: (i) the treatment condition of interest

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Take time to check your insurance coverage, explore savings programs, and plan ahead at the pharmacy for a smoother transition

Financial support and sponsorship This work was supported by grants from the National Science Foundation ( IOS-1557341 (HFN, MCR) and DMS-2038056 (AC)

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