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11-13 GLP-1 receptors are expressed in multiple tissues, therefore, GLP-1RAs have multiple mechanisms of action (Figure 2)

Research shows that 12-hour sustained stimulation leads to marked receptor downregulation, meaning the cell actually destroys receptors rather than recycling them

Some studies suggest combining GLP-1 therapy with metformin may provide additive benefits

At 12mg, it becomes 6mg per injection

Efficacy and safety of liraglutide added to insulin treatment in type 1 diabetes: the ADJUNCT ONE treat-to-target randomized trial

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