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doi: 10.1073/pnas.0704329104 318 FarahCMichelLYMBalligandJL

7 Conclusion and future directions PTDM remains a major barrier to long-term transplant success.This review advances the field by proposing a unifying gutimmunemetabolic axis and a multi-hit model integrating immunosuppressive therapy, microbiota dysbiosis, and host metabolic susceptibility