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Its substrate site-targeting mechanism inhibiting NNMT at the nicotinamide binding site provides selectivity over related methyltransferases and other enzymes in the NAD salvage pathway, making it a precise tool compound for studying NNMT-specific enzymatic activity in controlled laboratory systems

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Authorship All named authors meet the International Committee of Medical Journal Editors (ICMJE) criteria for authorship for this article, take responsibility for the integrity of the work as a whole, and have given their approval for this version to be published

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Animal studies also demonstrate its ability to reduce seizure threshold, alleviate depression-like behaviors, and modulate dopaminergic and serotonergic systemseven showing synergy with antidepressants and anxiolytics in preclinical models