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Side Effects: Cardiac arrhythmias Dyspnea Nausea Vomiting Headache Pharmacokinetics: Dopamines onset of action occurs within five minutes of intravenous administration, and with dopamines plasma half-life of about two minutes, the duration of action is less than ten minutes

Current management strategies include optimising blood glucose control, dietary modifications and supportive nutrition

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While mammals have only one copy of the GPX4 gene, fish have two copies, GPX4a and GPX4b

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33-35 Although single studies evaluating the efficacy of metformin for treatment of hirsutism in patients with PCOS have shown potential benefits, 36-38 meta-analyses showed no significant effects of metformin compared to placebo or oral contraceptives and decreased benefits compared to spironolactone and flutamide