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Our previous studies in mice with a homozygotic deletion of Glud1 in CNS (C- Glud1 / mice) revealed elevated hippocampal cerebral blood volume (CBV) and glutamate levels in medial PFC (mPFC) and hippocampus, along with baseline and amphetamine-induced hyperlocomotion

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fMRI was also used to evaluate the central effects of GLP-1RAs

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