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[9] [10] Classification [edit] Protein sequence and structure are important additional classification criteria for the three superfamilies (cytosolic, mitochondrial, and MAPEG) of GSTs: while classes from the cytosolic superfamily of GSTs possess more than 40% sequence homology, those from other classes may have less than 25%

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And so, I think there'd be plenty of reason to think there's going to be spillovers somewhere