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The de novo biosynthesis of sphingolipids, catalyzed by serine palmitoyltransferase, connects serine and mitochondrial alanine metabolism to membrane lipid diversity, a mechanism that could be exploited to induce tumor cell death under metabolic stress, such as in an amino acid-deprived microenvironment [126]
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Endothelial dysfunction is now recognized as a central mechanism driving dysautonomia and postural orthostatic tachycardia syndrome (POTS)
The study, GLP-1 Obesity Treatment without Diabetes: Clinical Outcomes and Cost Offsets , analyzed data from 16 million commercially insured members to evaluate the impact of GLP-1 drugs on obesity-related health outcomes
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