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20 mg vial Concentration: 20 mg 3 mL = 6.667 mg/mL (equivalently 6,667 mcg/mL) Dose in mg: 250 mcg = 0.25 mg Draw volume: 0.25 mg 6.667 mg/mL = 0.0375 mL Syringe units: 0.0375 mL 100 = 3.75 units 4 units on a U-100 syringe On the 20 mg vial, one documented dose is a very small draw about the 4-unit mark

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Mitochondrial density has increased enough to produce measurable performance differences