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Frequency Guidelines: Daily to Monthly Administration The frequency of vitamin B12 injections varies based on the deficiencys severity and the patients response

PMID: 33273451

An earlier 12-week trial in 300 obese adults produced a genuine positive signal the 1 mg daily dosing arm showed a statistically significant 2.8 kg mean weight loss versus 0.8 kg in the placebo group and that result is what justified moving into the larger Phase IIb trial

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At higher doses, it is also absorbed by passive diffusion across the gut wall, independently of intrinsic factor