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Targeting the IGF-1R: The tale of the tortoise and the hare

10.1186/s12885-021-08134-7 100 van der LeijF

Future therapeutic strategies should carefully balance the pro-fibrotic and anti-inflammatory functions of this pathway to achieve optimal clinical benefit

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Retatrutide , a triple-agonist targeting GLP-1, GIP, and glucagon receptors simultaneously, has shown weight loss exceeding 24% in clinical trials