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Novel biased GLP1 agonists described in the preclinical literature The first bespoke biased GLP1 agonist to be reported, P5, was obtained through an innovative strategy involving expression of single peptide sequences from an exendin4derived combinatorial peptide library, with peptides anchored to the cell surface via a flexible linker that allows autocrine activation of GLP1 receptors expressed in the same cell (Zhang et al., 2015)

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, 41 , 1119-1132, doi: Funding This work was financially supported by the Program 5-100 of the Peoples Friendship University of Russia

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This compounded injectable preparation combines semaglutidea long-acting glucagon-like peptide-1 (GLP-1) receptor agonistwith cyanocobalamin (vitamin B12) in a single subcutaneous injection

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