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The Pernicious Anaemia Society realises that healthcare workers are extremely vulnerable at this time and fully supports the efforts being made to minimise the threats to front-line health professionals

If reactions persist despite rotation, split the 100mg dose into 50mg twice daily (morning and evening) or switch to oral administration at 150mg to bypass subcutaneous absorption entirely

Neurological symptoms often develop gradually and may include: Paraesthesia : tingling or 'pins and needles' sensations, typically starting in the feet and hands Numbness : reduced sensation in the extremities, which may affect balance and coordination Burning pain : particularly in the feet, often worse at night Weakness : muscle weakness and difficulty walking Balance problems : unsteady gait and increased fall risk due to proprioceptive impairment Cognitive changes : memory problems, confusion, difficulty concentrating, and mood disturbances Haematological signs may accompany neurological symptoms and include fatigue, weakness, pallor, and shortness of breath due to megaloblastic anaemia

Animal studies have reported outcomes including reduced adiposity, improved insulin sensitivity, and altered lipid profiles, all without changes in food intake

Important Safety Considerations Both GHK-Cu and AHK-Cu are research compounds without FDA approval for any indication

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