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This leads to transcriptional repression of lipogenic regulatorsincluding sterol regulatory element-binding protein 1c (SREBP1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC)resulting in reduced hepatic steatosis, improved insulin sensitivity, and systemic metabolic restoration

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However, it can be depleted owing to aging, stress, poor nutrition, pollution, alcohol consumption, and diseases

The paper describes the fact that some patients are told to opt for PRP therapy because it does the same job