Drugs that do not readily integrate into the liposomal structure may result in lower encapsulation rates, leading to unpredictable drug release kinetics
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Here are some symptoms of undermethylation to look out for: [22] Elevated homocysteine levels Depression Irritability Anxiety Multiple miscarriages Multiple chemical sensitivities Sensitivity to anesthetics Red face that lasts after exercising Allergies Being prone to addiction High libido Obsessive-compulsive disorder (OCD) Low pain threshold Headaches/migraines Digestive problems (such as IBS) Brain fog (especially after protein-rich meals) Insomnia High estrogen levels/estrogen dominance Low energy/fatigue Muscle pain Low levels of neurotransmitters (dopamine, norepinephrine, and serotonin) Heavy menstrual periods with blood clots Flakey skin rash under your nose* Lowered immunity* *Although I havent seen this in the research, its been an observation for me personally, as well as for a few clients, that difficulty fighting off viral infections as well as having a red rash under the nose, seems to correlate with poor methylation

Clinically improves the appearance of uneven skin tone at 4 weeks*
And I might also add a caveat
Excitotoxicity, neuroinflammation and oxidant stress as molecular bases of epileptogenesis and epilepsy-derived neurodegeneration: The role of vitamin E