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A new side effect, dysesthesia (abnormal skin sensations like tingling or burning), emerged in Phase 3 trials at rates of 8.8% (9mg) to 20.9% (12mg)
However, unlike GLP-1R agonists, DPP-4 inhibitors do not cause significant reductions in body weight (Meneghini et al., 2011
This tri-agonist model allows researchers to dissect how hormonal signals converge to influence glucose homeostasis, insulin action, and fat storage, providing deeper insights than single-pathway agents
Stop use Pancreatitis: Cases of pancreatitis have been reported