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By this time next year, we will likely have multiple oral options, a triple agonist that has already been making splashes in the gray market, and a fundamentally different conversation about access

Intarcia started developing its lead therapy, a small, skinny bar implanted under the skin, for type 2 diabetes patients in 2016

The medications once-weekly dosing is made possible by a C20 fatty diacid chain, which extends tirzepatides half-life and helps maintain steady therapeutic levels

This lipid pattern is extremely atherogenic (artery-clogging) and dramatically increases cardiovascular risk

This was a revolutionary finding at the time, far surpassing older weight loss drugs

B.HellerJ.-O.et al (2013)