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In addition, Caveolin-1 (Cav-1), a 21-kDa integral plasma membrane protein is a well-known negative regulator of eNOS activity in vascular endothelial cells 17,18,19,20,21,22

Clancy TE, Moore FD Jr, Zinner MJ

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It is our strong opinion that not all patients with widespread pain and fatigue fit the classic definition of FMS per the ACR criteria