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Persistent inflammatory factors stimulate HSCs in the liver to secrete fibrotic factors that increase extracellular matrix (ECM) formation and ultimately lead to liver fibrosis (Eraky et al., 2018)

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Tolerability in the MASH trial mirrored the obesity data: nausea (66% vs

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Epinephrine was added to the assay mixture, containing tissue supernatant, and the change in extinction coefficient was followed at 480 nm in a spectrophotometer