The pivotal Wegovy trials showed that slow escalation (0.25 mg 0.5 mg 1 mg 1.7 mg) achieved sustained weight loss of 15% body weight in 68% of participants
When present in urine, these ketones can create a sweet, fruity, or sometimes described as "nail polish remover" odor
Most importantly, numerous other neuroprotective and neurotrophic growth factors like BDNF-analogs and LM11A-31 are currently being studied for their cognitive and therapeutic benefits, especially their ability to preserve and promote neural networks and neuron health, particularly in the setting of neurodegenerative diseases like Alzheimer's disease, FrontoTemporal Dementia (FTD), Parkinson's Disease (PD), and Lewy-Body Disease, as well as ischemic or traumatic neural injury (68a) (68b) (68c) (68d)
Insulin Resistance: GLP-1 meds improve insulin sensitivity, but stopping them can tip the balance
Important precautions include: Mounjaro may delay gastric emptying, potentially reducing the absorption of oral medications including oral contraceptives
SGLT2i: beyond the glucose-lowering effect
)
