doi: 10.1002/wsbm.1486 164 PavlovaNNThompsonCB
Numerous RCTs have demonstrated the efficacy of oral TA in the treatment of melasma.27 Melasma has several features suggestive of a photoaging disorder, such as neovascularization, basement membrane damage, and solar elastosis.28 TA appears to indirectly decrease metalloproteinase 1 activation and reduce the expression of proinflammatory cytokines, such as interleukin 6 and tumor necrosis factor
Medical Conditions: People with a personal or family history of medullary thyroid carcinoma (a type of thyroid cancer) should avoid semaglutide
Still, it does inhibit the infiltration of CD191 + B lymphocytes into the inflamed lamina propria (61)
These are licensed prescription-only medicines approved by the MHRA and the European Medicines Agency (EMA) specifically for weight management in defined patient groups (see NICE TA875 for semaglutide and NICE TA664 for liraglutide)
Campbell RN, Greathead AS, Myers DF, de Boer GJ
