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After incubation for 15 min in a 32 C water bath and 1 h at ambient temperature, the slices were loaded with Fura-2-AM (4 mM

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This magnitude of weight loss narrows the gap with bariatric procedures, although it remains below the average 25%-35% weight loss typically reported after sleeve gastrectomy or Roux-en-Y gastric bypass [6] , reinforcing the therapeutic potential of dual-pathway targeting