PubMed Ho, E.N., Kwok, W.H., Lau, M.Y., Wong, A.S., Wan, T.S., Lam, K.K., Schiff, P.J., Stewart, B.D
New Trends Experim Clin Psychiatry
Santis AG, Campanero MR, Alonso JL, Sanchez-Madrid F
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Huis group discovered a specific combination of three transcription factors consisting of GATA4, HNF1 and FOXA3, which converted p19 Arf/ mouse tail-tip fibroblasts to iHeps with a higher conversion efficiency ( Hnf1a and Foxa3 transduction was already sufficient to induce iHeps and addition of Gata4 enhanced the conversion efficiency ( Hnf1 and Foxa3 directly induced MEFs into hepatic stem cells which had the bipotential of differentiating into hepatocytes and cholangiocytes (Yu et al., 2013)
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