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200 Consequently, numerous preclinical and clinical efforts have targeted pathways through small-molecule inhibitors of Notch (e.g., -secretase inhibitors), Hedgehog (e.g., Smoothened (SMO) inhibitors), and PI3K/AKT/mTOR (e.g., rapamycin analogs, pan-PI3K inhibitors) to deplete CSC populations

Hence, while -tocopherol is the most common form of vitamin E in the American diet (9), its plasma and tissue concentrations are generally significantly lower than those of -tocopherol

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Medication is prescribed only when clinically appropriate