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Lentigines assume a particular importance when their presence is associated with a variety of inherited systemic conditions, including PeutzJeghers, LEOPARD (multiple lentigines) and Carneys syndromes, centrofacial lentiginosis, and LaugierHunziker syndrome (idiopathic lenticular mucocutaneous pigmentation)

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Glutathione is a powerful antioxidant that neutralizes these free radicals , protecting the skin from damage

Activation of the HPA axis during the training greatly increases the cortisol levels (112), which acts as a metabolic and catabolic hormone (113) by mobilizing the glucose (114), endogenous stores of amino acids (115), and fatty acids (116), enhances the availability of all fuel substrates