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That histamine, in turn, causes blood vessels to leak, leading to swollen, itchy hives

Genetic analysis of AIP in 50 non-familial acromegalic patients resistant to treatment with SS analogs revealed a low, but non-negligible, prevalence of AIP germline mutations (62), suggesting a role for AIP alterations in SS-resistance of sporadic GH-secreting adenomas

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On the other hand, M98K OPTN overexpression in RGC-5 cells induced autophagy that led to cell death 30

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